On Saturday October 14th, at the Âé¶¹´«Ã½ presented a first disclosure of NP1867; a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2. We showed, for the first time, that NP1867 functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples.
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